Animals used in research Benefits of animal research Research provides opportunities for scientists to improve the lives of both humans and animals. Many different animals are used for scientific studies, such as cows, dogs, cats, pigs, mice, rabbits and primates.
Browse all the reports by the Institute for Laboratory Animal Research (ILAR) available to read, download, and purchase from the National Academies Press. IMPORTANT: If you are a principal investigator planning to use live, vertebrate animals for research, research training, or biological testing, you must adhere to requirements in the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals and the Animal Welfare Act and Regulations. IACUC review and approval is required. History of animal research The use of animals in scientific experiments in the UK can be traced back at least as far as the 17th Century with Harvey’s experiments on numerous animal species aiming to demonstrate blood circulation.
Pennsylvania Society for Biomedical Research The animal research facility, also known as the vivarium, is a specially designed building type, which accommodates exquisitely controlled environments for the care and maintenance of experimental animals.
Animal research facilities are related to but distinct from research laboratories. The facilities are complex, and expensive to build and to operate, but they are vital to the support of a proper, safe, and humane research effort. Clients are pushing project design teams to create laboratories that are responsive to current and future needs; that encourage interaction among scientists from various disciplines; that help recruit and retain qualified scientists; and that facilitates partnerships and development.
Building Attributes Whether vivariums are embedded within a lab building, are in a separate structure connected to a lab building, or are independent free-standing structures, they share the same basic attributes. HLW International LLP Through the capabilities of their particular architecture and building systems, they maintain tight environmental control over the facility to avoid the introduction of contaminants or pathogens, and prevent the possibility of infectious outbreaks, and avoid the transmission of odors.
These facilities are fundamentally about the care and maintenance of the experimental animals. Promote maintainability and cleanliness.
Organize circulation to permit controlled flows of people, animals, material, supplies, and wastes. The ability of the operator to maintain and adapt environmental control within spaces and between circulation paths and to avoid contaminants or infection.
Cage sizing and cage systems are species-dependent and are governed by the standards set forth in the Guide for the Care and Use of Laboratory Animals.
These in turn influence room sizesroom environment, and circulation patterns. Research using animals is sensitive, and the design of these facilities requires a heightened awareness to the issues of security control to maintain confidentiality and to prevent unauthorized intrusions.
The continuous maintenance of environments in these facilities must be without failure, downtime, or disruption.
See Figures 1, 2, and 3 for examples. AHRs can be organized as individual rooms accessed from a corridor system or multiple rooms could be organized into self-contained suites.
Animal Housing Room for Dogs View enlarged plan Procedure Rooms—Proximate to AHRs and frequently interchangeable with them; they are a primary setting for research activity within the unit. The method of allowing researcher access under controlled conditions is a critical issue to be solved.
Barrier Elements—Airlocks, lockers, pass-through autoclaves. These provide the primary barrier and access control that separates the controlled animal care environment from external influences.
Cagewash—The hub for all cleaning, sanitizing, and husbandry activities.
These areas are dominated by equipment-generated heat and moisture. The major equipment items include pass-through rackwashers, tunnelwashers, pass-through autoclaves, bedding dispensers and dump stations, and bottle washing and filling stations.
Cage Storage—A necessary function, but a space consumer, which unfortunately is frequently short shrifted. Storage —A necessary space and function for feed, bedding, and equipment has to be incorporated into the operational flow and space allocation.
Quarantine—Isolated AHRs for suspect and incoming animals that could be a source of infection.
|Support OneGreenPlanet||This work opens up new opportunities to study how retinal ganglion cells connect with other vision-related brain regions and on the development of retinal prosthetics for restoring vision through nonsurgical procedures.|
Dedicated Receiving Dock —A dock specific to animal functions is generally required. An elevator dedicated to animal usage should be located near the dock. A "dirty" function that should not be proximate to "clean" areas.
Containment Facilities—Facilities for working with potentially infectious biological agents. They operate under negative pressure to prevent the escape of air to the general environment. Wastes and effluents are separately contained and decontaminated.
Sophisticated control and monitoring systems and equipment are employed to achieve closely controlled and regulated air pressurizations and flows.
Barrier Facilities—Facilities for working with immuno-compromised species. These operate under positive pressure to keep contaminants out. As in containment facilities, control and monitoring systems and equipment are utilized in barrier facilities to maintain the required pressures and flows. Veterinary Care—Lab and care functions, e.
Veterinary Office Space—Some provision for in-unit office spaces for veterinary care staff. Staff Support Areas—Break area, cafeteriasworkstation, lockers, and rest-room facilities.Our series, Animals in Research, profiles the top organisms used for science experimentation.
In this instalment, we look at the original lab rats: Rattus norvegicus. Rats have a long history in. The Research Defence Society (RDS; London, UK), an organization representing doctors and scientists in the debate on the use of animals in research and testing, welcomes the greater openness that the FOI Act brings to discussions about animal research.
In addition, the lab is an integral member of the USDA National Animal Health Laboratory Network (NAHLN), a network of diagnostic laboratories across the US that help detect nationally significant animal diseases such as influenza and Foot & Mouth Disease.
More animals used for research and testing may have a life beyond the lab as the Ministry for Primary Industries makes moves to support their rehoming.
The protection and welfare of animals is an area covered by a wide range of EU legislation. This includes the protection of wildlife, zoo animals, farm animals, animals in transport and animals used for scientific purposes.
Animal studies, whether for the development or production of new medicines. Division of Laboratory Animal Resources DLAR supports the biomedical research community at the University of Kentucky by providing the highest quality veterinary services and humane care and treatment to the animals in our care.